Paracetamol 500 mg Tablet

Paracetamol, also known as acetaminophen, is one of the most commonly used medications worldwide for relieving mild to moderate pain and reducing fever. Each tablet typically contains 500 mg of paracetamol as the active ingredient.

Mechanism of Action:

Paracetamol works primarily by inhibiting the synthesis of prostaglandins in the brain, particularly in the central nervous system (CNS). These chemicals are responsible for transmitting pain signals and inducing fever.

Unlike NSAIDs (like ibuprofen or aspirin), paracetamol has minimal anti-inflammatory activity, making it a gentler option on the stomach and suitable for a wide range of patients.

Dosage and Administration:

Adults and adolescents (12 years and older):

• 500 mg to 1000 mg (1–2 tablets) every 4 to 6 hours as needed

• Maximum daily dose: 4000 mg (8 tablets)

Children (6–12 years):

• Typically 250–500 mg every 4–6 hours

• Maximum 4 doses in 24 hours

Do not exceed the recommended dose. Overdose can cause serious liver damage.

Contraindications:

Do not use Paracetamol if:

• You have severe liver disease

• You are allergic to paracetamol or any of the tablet’s ingredients

 

Precautions:

• Use with caution in patients with:

  • Liver impairment

  • Alcohol dependence

  • Chronic malnutrition

• Avoid combining with other paracetamol-containing products to prevent unintentional overdose

 

Possible Side Effects:

Paracetamol is generally well tolerated. However, rare side effects may include:

Common:

• Usually none at therapeutic doses

Rare:

• Skin rash or allergic reaction

• Low blood pressure (with high doses)

• Liver damage in case of overdose

Seek immediate medical help if you experience:

• Yellowing of skin or eyes (signs of liver damage)

• Severe rash, itching, or swelling

 

Drug Interactions:

• Alcohol (increases liver toxicity risk)

• Warfarin (can enhance anticoagulant effect with long-term use)

• Certain anti-epileptic or anti-tuberculosis drugs may increase risk of liver damage

 

Storage Instructions:

• Store below 25°C (77°F)

• Keep in a dry place, away from sunlight

• Keep out of reach of children